金沙娱乐城

石晓伟，男，博士，教授，博士研究生导师。现任河北医科大学金沙娱乐城 药物化学教研室主任。主要从事《药物化学》《药物设计学》教学科研工作。河北省药学会药物化学专业委员会常务委员、药学科普专业委员会委员、中药分析委员会委员，河北省药物与卫生技术综合评估学会药品临床综合评价专业委员会委员。河北省科技特派员，石家庄市科技特派员。

主要研究方向为药物设计和化学生物学。主持河北省重点研发计划项目、河北省自然科学基金项目等共8项，参与国家自然科学基金项目2项和河北省自然科学基金项目3项，指导本科生获国家级大学生创新实验项目共2项。获河北省科技进步奖三等奖1项、发明专利4项。在Food Chem、Anal Bioanal Chem、J Chromatogr A、中草药、药学学报、中国医药工业杂志等国内外权威专业期刊已发表学术论文70余篇，其中以第一作者或通讯作者发表SCI论文16篇。参编《药物化学》教材2部，担任河北医科大学学报青年编委。

主持科研项目情况：

1. 河北省自然科学基金，H2023206028，2023.01-2025.12
2. 河北省中医药管理局科研计划项目，2024108，2024.01-2025.12
3. 河北省重点研发计划项目，20374801D，2020.06-2022.12
4. 河北省自然科学基金，H2020206067，2020.09-2022.12
5. 河北省自然科学基金，H2017206087，2017.01-2019.12
6. 河北省高等学校科学技术研究项目，QN2017098，2017.01-2019.12
发表论文代表作：
1) Chi Yuqian, Zhu Xiaoliang, Chen Yaxuan, Li Xin, Jiang Ziyi, Jian Xiaoyang, Lian Mengyuan, Wu Xiaodi, Wang Lei, Sun Mengmeng*, Shi Xiaowei*. Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4. International Journal of Biological Macromolecules, 2024, 268: 131502. （中科院一区TOP，IF:7.7）
2) Zhu Xiaoliang, Lin Mengmeng, Chi Yuqian, Li Xin, Jiang Ziyi, Jian Xiaoyang, Lian Mengyuan, Wu Xiaodi, Han Shuang*, Shi Xiaowei*. Qualitative and quantitative analysis of chemical components in Qianggan capsule by UHPLC-Q-TOF-MS/MS and LC-sMRM. Journal of Chromatography A, 2024, 1728: 465020. （中科院二区TOP，IF:3.8）
3) Xiang Jiahong, Wu Mengqi, Wang Jianchao, Lin Mengmeng, Sun Mengmeng, Li Xin, Xing Ruijuan, Guo Ran, Gu Jianmin, Lyu Tao, Wang Lei*, Shi Xiaowei*. Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate. Frontiers in Pharmacology, 2022, 13:1001308.（中科院二区，IF:4.4）
4) Zhang Bo, Li Xin, Liu Yan, Tao Zifei, Xiang Jiahong, Wu Yibing, Wang Lei, Wang Qiao, Shi Xiaowei*, Han Shuang*. A UHPLC-QTOF-MS/MS method with a superimposed multiple product ion strategy and esterase inhibitor improved sensitivity for the determination of xylocarpin H in rat plasma. Journal of Pharmaceutical and Biomedical Analysis, 2022, 216:114803. （中科院三区，IF=3.1）
5) Shi Xiaowei, Wu Yibing, Lv Tao, Wang Yufang, Fu Yan, Sun Mengmeng, Shi Qingwen*, Huo Changhong*, Wang Qiao, Gu Yucheng. A chemometric-assisted LC-MS/MS method for the simultaneous determination of 17 limonoids from different parts of Xylocarpus granatum fruit. Analytical and Bioanalytical Chemistry, 2017, 409(19): 4669-4679. （中科院二区，IF:3.8）
6) Shi Xiaowei, Wang Shuang, Qian Qi, Zhou Na, Qi Pengcheng, Mu Xiyan, Wang Qiao*. Herb–herb pharmacokinetic interaction between Glehniae radix and Ophiopogonis radix in rats using superimposed multiple product ion (SMPI) LC-HR-MS/MS. RSC Advances, 2017, 7(47): 29732-29741. （中科院三区，IF:3.9）
7) Yao Donggui, Wang Yufang, Huo Changhong*, Wu Yibing, Zhang Manli, Li Ligeng, Shi Qingwen, Kiyota Hiromasa, Shi Xiaowei*. Study on the metabolites of isoalantolactone in vivo and in vitro by ultra performance liquid chromatography combined with Triple TOF mass spectrometry. Food Chemistry, 2017, 214: 328-338. （中科院一区TOP，IF:8.5）
8) Yao Donggui, Li Zhe, Huo Changhong*, Wang Yufang, Wu Yibing, Zhang Manli, Li Ligeng, Shi Qingwen, Kiyota Hiromasa, Shi Xiaowei*. Identification of in vitro and in vivo metabolites of alantolactone by UPLC-TOF-MS/MS. Journal of Chromatography B, 2016, 1033: 250-260. （中科院三区，IF:2.8）
9) Shi Xiaowei, Shang Weiding, Wang Shuang, Xue Na, Hao Yanxia, Wang Yabo, Sun Mengmeng, Du Yumin, Cao Deying, Zhang Kai*, Shi Qingwen*. Simultaneous quantification of naproxcinod and its active metabolite naproxen in rat plasma using LC–MS/MS: Application to a pharmacokinetic study. Journal of Chromatography B, 2015, (978-979): 157-162. （中科院三区，IF:2.8）
10) Shi Xiaowei, Zhang Kai*, Xue Na, Su Linfei, Ma Gaixia, Qi Jinlong, Wu Yibing, Wang Qiao, Shi Qingwen*. Differentiation of genuine Inula britannica L. and substitute specimens based on the determination of 15 components using LC-MS/MS and principal components analysis. Food Chemistry, 2013, 141(4): 4019–4025. （中科院一区TOP，IF:8.5）
11) Shi Xiaowei, Liu Man, Zhang Min, Zhang Kerong, Liu Songchen, Qiao Shi, Shi Rui, Jiang Xijuan, Wang Qiao*. Identification of in vitro and in vivo metabolites of isoimperatorin using liquid chromatography/mass spectrometry. Food Chemistry, 2013, 141(1): 357–365. （中科院一区TOP，IF:8.5）
12) Shi Xiaowei, Liu Man, Sun Mengmeng, Wang Qiao, Liu Weina, Cao Deying*. Development of a LC–ESI-MS3 method for determination of nitrendipine in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56(5): 1101-1105. （中科院三区，IF:3.1）
获奖情况
张恺，石晓伟，薛娜，李林，杜玉民，郭海波。2017年获得河北省科技进步奖三等奖，第2名。2017JB3010-2。